Because hemophilia is a rare condition, people with hemophilia may not be well represented in studies that assess the safety of these drugs
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Moreover, both endogenous GLP-1 and GLP-1RAs interact with circumventricular organs (CVOs), such as the area postrema and subfornical organ, which lack a fully intact BBB
Exendin-4 was eventually developed into exenatide, a treatment for diabetes and the first GLP-1 receptor agonist approved for medical use
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Pen-sharing poses a risk for transmission of blood-borne pathogens Adverse Reactions Most common adverse reactions (incidence 5%) are: nausea, diarrhea, vomiting, constipation, abdominal pain, dysesthesia, headache, fatigue, dyspepsia, dizziness, abdominal distention, eructation, hypoglycemia in patients with T2D, flatulence, gastroenteritis, gastroesophageal reflux disease, and hair loss Drug Interactions When initiating Wegovy , consider reducing the dose of concomitantly administered insulin secretagogues or insulin to reduce the risk of hypoglycemia
